Nintendo's press conference at E3 2012 showcased a Zombi U gameplay demo. The Wii U-exclusive third-person shooter uses the Wii U Gamepad's screen in conjunction with your television. Players searching their inventory, for example, will see on their Wii U their list of available items, while on their television they will see their character rummaging through a bag.
The gamepad adds additional features to Zombi U gameplay, including sniping, door hacking, and shake free, which frees you from the grasp of zombies by shaking your Wii U (just don't shake it too hard, lest we hear of airborne Wii U smashing TV screens!).