Naughty Dog attended New York Comic-Con where we met up with Arne Meyer, who told us all about Naughty Dog's next project, The Last of Us. The demo you saw at E3 2012 was finally playable, but this time with a different strategy for completing it.
The Last of Us will take a page from the Uncharted book as it will focus on advanced AI. 20 years after the fall of civilization should leave the people left shaken, disturbed, and greatly effected by the change the world has experienced. The AI, both enemy and friendly, will reflect a more realistic attitude towards the choices gamers make.