Nintendo's upcoming Wii U console will be region-locked, just like the Wii before it. The company confirmed as much to CVG, though anyone who's familiar with Nintendo's past products shouldn't be too surprised. Region-locking goes all the way back to the original NES, though there are workarounds for region lockouts on many of the Nintendo platforms.
Microsoft's Xbox 360 console is also techincally region-locked, though this largely applies to digital content; publishers are permitted to release region-free or region-locked games as they like. It's the same for Sony, at least in terms of recent hardware, with an even longer list of region-free games available for PlayStation 3, PlayStation Vita, and PlayStation Portable.