Last night I played both Duke Nukem Forever and Alice: Madness Returns on my PC. For both games I was using a wired Xbox 360 controller half of the time and the other half of the time I was using my mouse and keyboard. I'd never used a controller with a PC game before but I found that, especially with Alice, the controller worked a lot better for me than the m/k controls. But in Duke, a mix of controls worked best. The first person shooter aspects worked better with a mouse, whereas the RC car parts were better with the controller. Long story short, I'm wondering if you've ever switched around your controls like this and if you've found that some games just work better one way or the other. Or, do you use weird hotkeys and settings when you play games that other people find abnormal? For example, I always use the "R" button for autorun in every game rather than "Numlock."
Morning Hangover: Weird Video Game Controls -- How Do You Play?