Nintendo of America and Team Ninja might be ready to blow our minds. Take a look at this description for Metroid: Other M from the official press release, which just hit my inbox.
"While much of the game is reminiscent of 2-D side-scrollers, players can switch the perspective into 3-D at any time as they explore the twisting passages of a derelict space station and delve deep into a cinematic, never-before-told story of bounty hunter Samus Aran’s past. This new approach uses a new control scheme in which players use the Wii Remote controller held sideways to battle enemies and navigate the expansive, gorgeous environments in classic Metroid fashion, then aim at the screen with the Wii Remote pointer to blast foes in first-person and hunt the world for clues and hidden passages."
Somehow, these teams have apparently crafted both a 2D and 3D Metroid game...simultaneously.
My brain feels like the end of an episode of Lost.