Nintendo and Team Ninja's Metroid: The Other M is expected to be our next adventure with Samus Aran, but does this indicate a brand-new direction for the franchise? Retro Studios is responsible for bringing Metroid into the third dimension with the Metroid Prime series, but it seemed Metroid Prime was done after after Metroid Prime 3: Corruption, with both Retro and Samus moving on.
"We are always planning to make new games in the Metroid Prime series," said Metroid Prime producer Kensuke Tanabe to the Official Nintendo Magazine in the UK. "Depending on the timing and the situation, we cannot deny the possibility of realising it on DS or DSi."
After Metroid Prime: Hunters, though, I'm not so sure I'd like to see it appear on DS.
Source: Official Nintendo Magazine