When it comes to quitting your job (something you probably shouldn’t be doing these days), the last thing you want to do is make it forgettable. You want people talking about it six months later. “Man, I still don’t know how Fred got all of those chickens in the air ducts. What a hero.” Something like that. Or, if you happen to be the indie developer Farbs, and you feel that it's time to part ways with 2K Australia, you could just retool a classic game like Super Mario Bros. and get your message across that way.
If you want to see what an awesome job-quitting-based game looks like, you can play it at Farbs’ site.
Is it too early to speculate about a sequel?