Jerry Holkins and Mike Krahulik, the creators of the Penny Arcade webcomic and the Penny Arcade Expo in Seattle, mentioned in an interview with 1up that starting in 2010 they will hold a second yearly PAX event in Boston. The new PAX is still in the early planning stages at the moment, but will act as a compliment to the existing PAX in Seattle, not a replacement. This was apparently spawned by a presentation the animated duo gave at MIT a few years back, where they swore they would return to Boston...at some point in the future.
I, for one, welcome this new event. Boston is a beautiful city (at the right time of the year) and has a wonderful setting for an event such as this. May I suggest holding the event sometime in the spring or fall? Trust me, you don't want to get stuck in 3 feet of snow in January or in 110 degree heat with 98% humidity in August.