Allen Reiss, a Stanford professor, has published a paper in the Journal of Psychiatric Research on males and gaming. Basically, it states that certain parts of the brain are more active in males than females while playing games; the mesocorticolimbic centre to be exact. This is the part of the brain typically associated with reward and addiction.
It's not a matter of comprehension as females understand the rules and how to win. They just don't care as much about gaining territory and conquering challenges as their male counterparts.
So, guys like games more than girls like games. Thanks. Glad he makes a zillion dollars to work on such groundbreaking phenomena.
gamepolitics.com: Games Are a Guy Thing, Say Researchers