It seems that Naughty Dog have optioned the rights to Uncharted: Drake's Fortune to a company by the name of Atlas Entertainment for the purpose of making it into a movie. Atlas Entertainment is the production entity responsible for making Twelve Monkeys and Three Kings, so it's not some rinky-dink organization.
We kinda dig the idea of the Uncharted movie. Think about it, it'll be kind of like a Raiders of the Lost Ark or Romancing the Stone kind of adventure film. That could certainly be fun to watch. In any event, it'll be a real miracle if it ever actually gets made, so we'll keep you posted.
Kotaku.com: Are We Going To Get An Uncharted Movie?