Okay, this research study by England's Wellcome Trust isn't exactly a videogame, but it's close: In an effort to study paranoid reactions, (presumably mad) scientists created a virtual reality subway ride to determine if test subjects would become paranoid.
Turns out, paranoid people are more likely to interpret avatar's innocent actions as threatening or mocking.
As for the game: We like the mid-90s style VR helmet, but the graphics are kind of assy, and while riding the fake train did make us excessively paranoid, players can't hit anyone, so it's difficult to respond.
We give "Paranoid Tube Ride" a 2 out of 5.
Wellcome Trust: Virtual reality Tube ride reveals extent of public paranoia