According to GameDaily BIZ, the Guitar Hero franchise will be changing developers from Harmonix to Neversoft.
As you know, Neversoft has knocked pretty much everything out of the park for Activision - from Spiderman on the PS1 (probably the best. spidey game. ever.) to the venerable Tony Hawk Franchise to Gun... all fantastic games.
Assuming this is true (its couched as coming from an "anonymous industry source") it'll be interesting to see what they can do with Guitar Hero III. I for one welcome their new overlords.